Since their 2010 self-titled debut, The Secret Sisters have brought their spellbinding harmonies to songs that untangle the thorniest aspects of life and love and womanhood. In the making of their new album, Mind, Man, Medicine, Alabama-bred siblings Laura Rogers and Lydia Slagle found their songwriting transformed by a newfound sense of self-reliance and equanimity, threading their lyrics with hard-won insight into the complexities of motherhood, commitment, compassion, and self-preservation in an endlessly chaotic world. Centered on a kaleidoscopic sound that boldly blurs the edges of country-folk, the duo’s fifth full-length ultimately confronts many of modern life’s harshest challenges while leading the listener toward a more open hearted state of mind.

“In our previous records there was a feeling that we had something to prove, but now we’re leaning toward a place of peaceful acceptance and trying to stay immersed in the present,” says Slagle, noting that their shared experience in parenting young  children greatly informed that shift in perspective. “There are definitely still moments of frustration and anger on this album, but there’s also a little more light,” Rogers adds. “I think a lot of that came from getting older, and from letting go of the pressure we put on ourselves in the past. We finally reached the point of saying, ‘Let’s just write the songs honestly as we can, and trust that they’ll reach whoever they’re meant to reach.’”

The follow-up to Saturn Return—their 2020 Grammy-nominated LP co-produced by Brandi Carlile and lavishly praised by the likes of Rolling Stone—Mind, Man, Medicine finds The Secret Sisters co-producing alongside Ben Tanner (Alabama Shakes, St. Paul & the Broken Bones) and John Paul White (formerly of Grammy-winning duo the Civil Wars). “On Saturn Return we’d gotten much more confident as far as directing the sound of the record and knowing how to capture our voices in the most honest way, so it felt like the right time for our first foray into production,” says Rogers. The latest in a series of critically lauded releases, the album came to life at FAME Studios (the historic spot in their hometown of Muscle Shoals) and at Sun Drop Sound in nearby Florence, with contributions from such esteemed musicians as Alabama Shakes bassist Zac Cockrell and legendary multi-instrumentalist Larry Campbell (Paul Simon, Willie Nelson, Levon Helm).

Referring to The Secret Sisters’ latest chapter as “one where we seek, savor, and settle,” the duo lifted the title to Mind, Man, Medicine from a lyric in “Same Water”: a gorgeously bluesy meditation on the search for healing in a profoundly troubled world, channeling both weariness and empathy with. soulful conviction. “There’s a line in ‘Same Water’ that says ‘Mind or man or medicine/I have tried them all,’ which feels like it encompasses everything we were trying to say on this record,” Slagle explains. “In a lot of these songs we’re struggling with our own minds and emotions, with our relationships, and with whatever we’re using to try to cope and find relief.”

In a lovely introduction to the album’s expansive sound, Mind, Man, Medicine opens on a hypnotic number called “Space.” With its stark yet sprawling arrangement of luminous piano, otherworldly synth, and moody guitar tones—achieved in part through Slagle’s performance on rubber bridge guita —“Space” infuses an element of dreamy psychedelia into The Secret Sisters’ contemplation of human connection and all its intricacies. “It’s about recognizing that loving someone isn’t always going to be easy, especially when they have a belief or a political leaning that you disagree with,” says Rogers. “It’s so simple to project your desires onto someone else, but in the end you have to hold onto what you love and value about them, even when it gets tough.”